Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management

Author:

Thompson George R.12ORCID,Jenks Jeffrey D.34,Baddley John W.5,Lewis James S.6,Egger Matthias7,Schwartz Ilan S.4ORCID,Boyer Johannes7,Patterson Thomas F.8,Chen Sharon C.-A.910,Pappas Peter G.11,Hoenigl Martin712ORCID

Affiliation:

1. Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center, Sacramento, California, USA

2. Department of Medical Microbiology and Immunology, University of California-Davis, Davis, California, USA

3. Durham County Department of Public Health, Durham, North Carolina, USA

4. Division of Infectious Diseases, Department of Medicine, Duke University, Durham, North Carolina, USA

5. Department of Medicine, Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA

6. Department of Pharmacy, Oregon Health & Science University, Portland, Oregon, USA

7. Division of Infectious Diseases, ECMM Excellence Center for Medical Mycology, Department of Medicine, Medical University of Graz, Graz, Austria

8. Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center, San Antonio, Texas, USA

9. Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Sydney, New South Wales, Australia

10. Centre for Infectious Diseases and Microbiology, Westmead Hospital, The University of Sydney, Sydney, New South Wales, Australia

11. Department of Medicine Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA

12. BioTechMed-Graz, Graz, Austria

Abstract

Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use.

Funder

NIH

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

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