Affiliation:
1. From the Animal Health Laboratory, Department of Agriculture, Perth, Western Australia
Abstract
The gross- and histo-pathology in relation to the main clinical features of inappetence, loss of body weight and jaundice, of some 500 sheep in various stages of lupinosis is described. The gross changes occurring in the liver, the principal organ affected, of pen trial sheep receiving pure diets of toxic lupins were classified as (a) early, (b) subacute, and (c) chronic. The corresponding histological features were found to be (a) eosinophilic and nuclear degeneration of hepatocytes with or without granular formation in the cytoplasm, (b) accumulation of granular degenerated hepatocytes in centrilobular areas with proximate fibrosis, and (c) portal tract fibrosis, bile duct cell and Kupffer cell proliferations, and cirrhosis. The granular degenerated hepatocytes were found to be composed mainly of lipofuscins and haemosiderin with small admixtures of other cell decomposition products. Their probable derivation is by cellular peroxidation mechanisms under the influence of increased serum and liver iron and copper in association with toxins forming at times on lupin roughage. Haemosiderosis of liver, spleen and kidney was correlated along with nutritional deficits in the pathogenesis of lupinosis.
Cited by
35 articles.
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