Effect of p-aminopropiophenone (PAPP), a cyanide antidote, on cyanide given by intravenous infusion-Reference-Cited by-同舟云学术

Effect of p-aminopropiophenone (PAPP), a cyanide antidote, on cyanide given by intravenous infusion

Published:1987-03 Issue:2 Volume:6 Page:133-137
ISSN:0144-5952
Container-title:Human Toxicology
language:en
Short-container-title:Human Toxicology

Author:

Bright J.E.¹,Marrs T.C.¹

Affiliation:

1. Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK

Abstract

1 Beagle bitches were infused with potassium cyanide solution after protection with p-aminopropiophenone (PAPP). 2 Methaemoglobin levels fell very rapidly after the start of the infusion. 3 Whole blood and plasma cyanide estimations revealed that most of the cyanide was sequestered inside the red cells. 4 Animals survived a supralethal dose of cyanide when protected with PAPP.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032718700600205

Reference22 articles.

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4. Urinary excretion of N-hydroxy derivatives of some aromatic amines by rabbits, guinea pigs, and dogs

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