Kinetics of Methaemoglobin Production (1)-Reference-Cited by-同舟云学术

Kinetics of Methaemoglobin Production (1)

Published:1986-09 Issue:5 Volume:5 Page:295-301
ISSN:0144-5952
Container-title:Human Toxicology
language:en
Short-container-title:Human Toxicology

Author:

Marrs T.C.¹,Bright J.E.¹

Affiliation:

1. Pathology and Clinical Toxicology Section, Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK

Abstract

Methaemoglobin profiles have been studied by using ISIS, a simulation package, and NONLIN, a ion-linear least-squares analysis regression program. A simple kinetic model which satisfactorily describes methaemoglobin profiles after p-aminopropiophenone (PAPP) administration and 4-dimethylaminophenol (DMAP) administration has been developed. The two compounds differed nainly in their effective rates of elimination. The model less satisfactorily described methaemoglobin profiles after p-hydroxyaminopropiophenone (PHAPP) administration.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032718600500501

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