The protective effects of omega-3 fatty acid against toluene-induced neurotoxicity in prefrontal cortex of rats-Reference-Cited by-同舟云学术

The protective effects of omega-3 fatty acid against toluene-induced neurotoxicity in prefrontal cortex of rats

Published:2012-10-18 Issue:11 Volume:31 Page:1179-1185
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Meydan S¹,Altas M²,Nacar A³,Ozturk OH⁴,Tas U⁵,Zararsiz I⁶,Sarsilmaz M⁷

Affiliation:

1. Department of Anatomy, Faculty of Medicine, Mustafa Kemal University, Tayfur Ata Sokmen, Hatay, Turkey

2. Department of Neurosurgery, Faculty of Medicine, Mustafa Kemal University, Tayfur Ata Sokmen, Hatay, Turkey

3. Department of Histology and Embryology, Faculty of Medicine, Mustafa Kemal University, Tayfur Ata Sokmen, Hatay, Turkey

4. Department of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Tayfur Ata Sokmen, Hatay, Turkey

5. Department of Anatomy, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey

6. Department of Anatomy, Medical Faculty, Mevlana University, Konya, Turkey

7. Department of Anatomy, Medical Faculty, Sifa University, Izmir, Turkey

Abstract

Objective: Toluene is used as an organic solvent, and it has neurotoxic effects. Omega-3 is an essential fatty acid required for brain development. The aim of this study was to investigate the protective effects of omega-3 fatty acid against toluene-induced neurotoxicity in prefrontal cortex of rats. Materials and methods: A total of 21 male Wistar rats were divided into three groups with seven rats in each group. Rats in group I were the controls. Toluene was intraperitoneally injected into the rats of group II with a dose of 0.5 ml/kg. Rats in group III received omega-3 fatty acid with a dose of 0.4 g/kg/day while exposed to toluene. After 14 days, all the rats were killed by decapitation. Enzymatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and the level of malondialdehyde (MDA) were spectrophotometrically studied in the prefrontal cortex of rats. Results: Enzymatic activities of SOD and GSH-Px were decreased, and MDA levels were significantly increased in rats treated with toluene compared with the controls. However, the increased SOD and decreased GSH-Px enzymatic activities and MDA levels were detected in the rats administered with omega-3 fatty acid while exposed to toluene. Conclusion: The results of this experimental study indicate that omega-3 fatty acid treatment can prevent toluene-induced neuronal damage in the prefrontal cortex of rats.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0960327112457187

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