Aqueous extract of Securidaca longepedunculata root induce redox imbalance in male rat liver and kidney-Reference-Cited by-同舟云学术

Aqueous extract of Securidaca longepedunculata root induce redox imbalance in male rat liver and kidney

Published:2010-02-09 Issue:8 Volume:29 Page:679-688
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Ajiboye TO¹,Salau AK²,Yakubu MT³,Oladiji AT³,Akanji MA³,Okogun JI⁴

Affiliation:

1. Phytomedicine and Toxicology Research Laboratory, Department of Biochemistry, University of Ilorin, Ilorin, Nigeria,

2. Biochemistry and Nutrition Unit, Department of Chemical Sciences, Fountain University, Osogbo, Nigeria

3. Phytomedicine and Toxicology Research Laboratory, Department of Biochemistry, University of Ilorin, Ilorin, Nigeria

4. Medicinal Plant Research and Traditional Medicine Department, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria

Abstract

The effect of aqueous extract of Securidaca longepedunculata root on redox homeostasis in male rat liver and kidney was investigated. Rats were grouped into four: A, B, C and D, where A (the control) received orally 1 mL of distilled water; B, C and D (test groups) received orally 200, 400 and 800 mg/kg body weight of the extract, respectively, for 28 days. Extract administration significantly reduced (p < .05) alkaline phosphatase activity in the liver and kidney with corresponding increases in the serum. Acid phosphatase activity increased significantly (p < .05) in the liver and kidney, while there was no significant change (p > .05) in the serum acid phosphatase activity. There was also significant decrease (p < .05) in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase in the liver and kidney. Liver and kidney levels of GSH, vitamins C and E were also significantly reduced (p < .05). Serum malonidialdehyde and lipid hydroperoxide increased significantly (p < .05) in all the extract-treated groups. The available data from this study revealed that aqueous extract of S. longepedunculata root exerted its toxicity in the animals by depleting the antioxidant systems. This may consequently expose the cells and cellular macromolecules to oxidative damage by reactive oxygen species generated either from the metabolism of the extract or other in vivo means.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0960327109357218

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