Gender-related propensity score match analysis of ECMO therapy in postcardiotomy cardiogenic shock in patients after myocardial revascularization

Author:

Gerfer Stephen1ORCID,Gaisendrees Christopher1ORCID,Djordjevic Ilija1ORCID,Ivanov Borko1ORCID,Merkle Julia1ORCID,Eghbalzadeh Kaveh1,Schlachtenberger Georg1,Rustenbach Christian1,Sabashnikov Anton1,Kuhn-Régnier Ferdinand1,Mader Navid1,Wahlers Thorsten1

Affiliation:

1. Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany

Abstract

Background: Gender is known to influence the pathophysiology and pathogenesis of the coronary vascular disease. Data on gender-related differences in patients with veno-arterial extracorporeal membrane oxygenation due to postcardiotomy cardiogenic shock is lacking in current literature. We aimed to analyze the impact of gender on intraoperative and short-term outcomes of vaECMO patients after coronary surgery and postcardiotomy cardiogenic shock. Methods: Between 2006 and 2017, a total of 92 patients with PCS after CABG underwent vaECMO-implantation at our institution. After a 1:1 propensity score match (PSM) for relevant preoperative data, we identified a cohort of 32 patients, 16 males, and 16 females. Periprocedural and short-term outcome data were analyzed with respect to sex differences. Results: The mean age was 64 ± 11 years, and 79% ( n = 73) were male patients. Clinical outcomes showed a 30-day all-cause mortality of 64% ( n = 59). After PSM, male patients showed a significantly smaller number of arterial grafts (0.4 ± 0.53 male vs 1.1 ± 0.7 female; p = 0.037). Thirty-day all-cause mortality did not differ between the groups (56% male vs 75% female; p = 0.262). In general, short-term outcome data were comparable without significant differences for the matched groups. Conclusion: Gender has no impact on patients with vaECMO therapy due to PCS in isolated coronary surgery.

Publisher

SAGE Publications

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Safety Research,Radiology Nuclear Medicine and imaging,General Medicine

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