Potassium Channels, Memory T Cells, and Multiple Sclerosis-Reference-Cited by-同舟云学术

Potassium Channels, Memory T Cells, and Multiple Sclerosis

Published:2005-12 Issue:6 Volume:11 Page:550-562
ISSN:1073-8584
Container-title:The Neuroscientist
language:en
Short-container-title:Neuroscientist

Author:

Beeton Christine¹,Chandy K. George²

Affiliation:

1. Department of Physiology and Biophysics, Medical School, University of California, Irvine

2. Department of Physiology and Biophysics, Medical School, 346-D Med. Sci. I, University of California, Irvine, Irvine, CA 92697

Abstract

Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal damage that result in disabling neurological deficits. Here the authors explain the rationale for the use of inhibitors of the Kv1.3 K+ channel in immune cells as a therapy for multiple sclerosis and other autoimmune disorders.

Publisher

SAGE Publications

Subject

Neurology (clinical),General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/1073858405278016

Reference118 articles.

1. CD27: a memory B-cell marker

2. The role of B cells and autoantibodies in multiple sclerosis

3. Potent Kv1.3 inhibitors from correolide—modification of the C18 position

4. Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine

5. Selective Blocking of Voltage-Gated K+ Channels Improves Experimental Autoimmune Encephalomyelitis and Inhibits T Cell Activation

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