Linezolid, a Novel Oxazolidinone Antibiotic: Assessment of Monoamine Oxidase Inhibition Using Pressor Response to Oral Tyramine

Author:

Antal Edward J.,Hendershot Pamela E.,Batts Donald H.,Sheu Wang-Pui,Hopkins Nancy K.,Donaldson Kirsteen M.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference22 articles.

1. Pawsey SD Daley-Yates PT Wajszczuk CP Stalker DJ U-100766 safety, toleration and pharmacokinetics after oral and intravenous administration [abstract F151] May 1996

2. Martin JP Herberg JT Slatter JG Dupuis MJ Although a novel microtiter-plate assay demonstrates that linezolid (PNU-100766) is a weak, competitive (reversible) inhibitor of human monoamine oxidase (MAO A), no clinical evidence of MAO A inhibition in clinical trials has been observed September 1998

3. Hypertensive krisen unter reversiblen hemmstoffen der monoaminoxidase;Bieck;Psychiat Prax,1989

4. Tyramine studies and the safety of MAOI drugs;Simpson;J Clin Psychiatry,1984

5. Linezolid: pharmacokinetic and pharmacodynamic evaluation of co-administration with pseudoephedrine HCl, phenylpropanolamine HCl and dextromethorphan HBr;Hendershot;J Clin Pharmacol,2001

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