Population Pharmacokinetics and Pharmacodynamics of Gabapentin After Administration of Gabapentin Enacarbil
Author:
Affiliation:
1. XenoPort, Inc; Santa Clara, CA,; USA
2. Pharmacyclics, Inc; Sunnyvale, CA,; USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1177/0091270012439209/fullpdf
Reference31 articles.
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2. XP13512 [(±)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug, I: design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters;Cundy;J Pharmacol Exp Ther,2004
3. Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin;Cundy;J Clin Pharmacol,2008
4. Pharmacokinetics and tolerability of single escalating doses of gabapentin enacarbil: a randomized-sequence, double-blind, placebo-controlled crossover study in healthy volunteers;Lal;Clin Ther,2009
5. Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine;Lal;Br J Clin Pharmacol,2010
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