Probing the Structure of the Sars Coronavirus Using Scanning Electron Microscopy-Reference-Cited by-同舟云学术

Probing the Structure of the Sars Coronavirus Using Scanning Electron Microscopy

Published:2003-02-01 Issue:2 Volume:9 Page:287-289
ISSN:1359-6535
Container-title:Antiviral Therapy
language:en
Short-container-title:Antiviral Therapy

Author:

Lin Yun¹²,Yan Xiyun¹,Cao Wuchun³,Wang Chaoying⁴,Feng Jing¹²,Duan Jinzhu¹²,Xie Sishen⁴

Affiliation:

1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing, China

2. State Key Laboratory of Microbial Resources, Institute of Microbiology, CAS, Beijing, China

3. Department of Epidemiology, Institute of Microbiology and Epidemiology, Beijing, China

4. Center for Condensed Matter Physics, Institute of Physics, CAS, Beijing, China

Abstract

A novel coronavirus, SARS-CoV, has been confirmed to be the aetiological agent of SARS. Transmission electron microscope (TEM) images played an important role in initial identification of the pathogen. In order to obtain greater morphological detail of SARS-CoV than could be obtained by TEM, we used ultra-high resolution scanning electron microscopy (SEM) to image the virus particles. We show here the three-dimensional appearance of SARS-CoV. Enhanced detail of the ultrastructure reveals the trimeric structure of the 10–20 nm spikes on the virion surface. These results contribute to characterization of the SARS agent and development of new antiviral strategies.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/135965350400900204

Reference6 articles.

1. Lung pathology of fatal severe acute respiratory syndrome

2. A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

3. Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

4. Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome

5. A complete sequence and comparative analysis of a SARS-associated virus (Isolate BJ01)

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