The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease?

Author:

Bien Justyna1,Palagani Vindhya2,Bozko Przemyslaw3

Affiliation:

1. Witold Stefanski Institute of Parasitology of the Polish Academy of Sciences, Warsaw, Poland

2. Department of Internal Medicine I, Faculty of Medicine, Tübingen University, Tübingen, Germany

3. Department of Internal Medicine I, Faculty of Medicine, Tübingen University, Otfried-Müller-Straße 10, 72076 Tübingen, Germany

Abstract

Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological conditions like Clostridium difficile infection or inflammatory bowel disease (IBD). In this review, we focus on the role of microbial dysbiosis in initiation of C. difficile infection and IBD, and we also touch upon the role of specific pathogens, particularly C. difficile, as causative agents of IBD. We also discuss the molecular mechanisms activated by C. difficile that contribute to the development and exacerbation of gastrointestinal disorders.

Publisher

SAGE Publications

Subject

Gastroenterology

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