Retinal neurodegeneration in age-related macular degeneration

Author:

Barresi Costanza12ORCID,Chhablani Jay3ORCID,Dolz-Marco Rosa4ORCID,Gallego-Pinazo Robero4,Berni Alessandro12ORCID,Bandello Francesco12ORCID,Borrelli Enrico12ORCID

Affiliation:

1. Vita-Salute San Raffaele University Milan, Milan, Italy

2. IRCCS San Raffaele Scientific Institute, Milan, Italy

3. UPMC Eye Centre, University of Pittsburgh, Pittsburgh, PA, USA

4. Unit of Macula, Oftalvist Clinic, Valencia, Spain

Abstract

Age-related macular degeneration (AMD) is a complex and multifactorial disease characterized by the damage of the unit comprised of the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. Although the outer retina appears to be mainly affected in this disorder, several evidences exhibit that also the inner retina may be impaired. In this review we will provide a description of the prominent histologic and imaging findings suggesting an inner retinal loss in these eyes. In details, structural optical coherence tomography (OCT) technology proved either the inner and outer retina is impacted by AMD and that these two impairments are associated. Therefore, the purpose of this review is to provide a description of the role of neurodegeneration in AMD in order to better understand the relationship between neuronal loss and the outer retinal damage in this disease.

Publisher

SAGE Publications

Subject

Ophthalmology,General Medicine

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