A Strict Low Protein Diet during the Predialysis Period Suppresses Peritoneal Permeability at Induction of Peritoneal Dialysis

Author:

Hasegawa Takeshi12,Yoshimura Ashio1,Hirose Makoto1,Komukai Daisuke1,Tayama Hironori1,Watanabe Susumu1,Koiwa Fumihiko1,Yamazaki Shin2,Ideura Terukuni1

Affiliation:

1. Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama;

2. Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine and Public Health, Kyoto, Japan

Abstract

Background The factors that predict baseline peritoneal permeability remain largely unknown. We noticed that patients that adhered to a strict low protein diet (LPD) during the predialysis period seldom showed high peritoneal permeability on the peritoneal equilibration test (PET) at the introduction of peritoneal dialysis (PD). Therefore, we investigated whether a strict LPD during the predialysis period affects peritoneal permeability. Method We retrospectively analyzed 37 patients that started PD in a single Japanese center. Patients were divided into group A and group B by the median amount of daily protein intake (PI) during the predialysis period using urine collected over 24 hours. Results There were no differences between groups A and B in age, gender, proportion of diabetic nephropathy, blood pressure, body mass index, or body surface area. There were also no differences between the groups in laboratory findings, including hematocrit, serum albumin, and serum creatinine. The PETs showed a significantly lower dialysate-to-plasma ratio of creatinine at 4 hours (Cr D/P) for group A than for group B ( p = 0.02). Furthermore, a significant positive correlation between Cr D/P and PI was observed ( r = 0.53, p < 0.01). Conclusion It is suggested that a strict LPD during the predialysis period may suppress peritoneal permeability at induction of PD.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Protein-Restricted Diets Plus Keto/Amino Acids - A Valid Therapeutic Approach for Chronic Kidney Disease Patients;Journal of Renal Nutrition;2012-03

2. Low-Protein Diet Supplemented with Keto Acids Is Associated with Suppression of Small-Solute Peritoneal Transport Rate in Peritoneal Dialysis Patients;International Journal of Nephrology;2011

3. In Reply to “Predialytic Period and Baseline Peritoneal Membrane Status: Any Connection?”;Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis;2010-07

4. Predialytic Period and Baseline Peritoneal Membrane Status: Any Connection?;Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis;2010-05

5. Predialysis Interventions for Postdialysis Outcomes;Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis;2009-05

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