Low-Protein Diet Supplemented with Keto Acids Is Associated with Suppression of Small-Solute Peritoneal Transport Rate in Peritoneal Dialysis Patients

Abstract

Objective.We investigate whether low-protein diet would show benefits in suppressing peritoneal transport rate in peritoneal dialysis (PD) patients.Methods.This is a supplemented analysis of our previously published trial, which randomized 60 PD patients to receive low- (LP: dietary protein intake of 0.6–0.8 g/kg/d), keto-acid-supplemented low- (sLP: 0.6–0.8 g/kg/d with 0.12 g/kg/d of keto acids), or high- (HP: 1.0–1.2 g/kg/d) protein diet and lasted for one year. In this study, the variations of peritoneal transport rate were assessed.Results.While baseline D/Pcr(dialysate-to-plasma concentration ratio for creatinine at 4 hour) and D/D0glu(dialysate glucose at 4 hour to baseline dialysate glucose concentration ratio) were similar, D/Pcrin group sLP was lower, and D/D0gluwas higher than those in the other two groups (P<0.05) at 12th month. D/D0gluincreased (P<0.05), and D/Pcrtended to decrease,(P=0.071)in group sLP.Conclusions. Low-protein diet with keto acids may benefit PD patients by maintaining peritoneum at a lower transport rate.