Short-term responses of selected endocrine parameters in juvenile rainbow trout (Oncorhynchus mykiss) exposed to 4-nonylphenol

Author:

Naderi Mohammad1,Zargham Davood2,Asadi Asad3,Bashti Tayebeh4,Kamayi Kianoosh5

Affiliation:

1. Department of Marine Biology, Faculty of Marine Science, Khorramshahr University of Marine Science and Technology, Khorramshahr, Islamic Republic of Iran

2. Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Islamic Republic of Iran

3. Department of Fisheries, Faculty of Marine Natural Resources, Khorramshahr University of Marine Science and Technology, Khorramshahr, Islamic Republic of Iran

4. Shahid Motahari Genetic Research Center for Coldwater Fishes, Iraninan Fisheries Research Organization, Yasuj, Islamic Republic of Iran

5. Department of Fisheries, Faculty of Natural Resources, Islamic Azad University, Bandar Abbas Branch, Bandar Abbas, Islamic Republic of Iran

Abstract

The synthetic organic compound 4-nonylphenol (4-NP) has been shown to have a wide range of adverse effects on the endocrine system of various animals including fish. The present study evaluated the potential effects of 4-NP on vitellogenin (VTG) synthesis, steroid, and thyroid hormone concentrations in both juvenile male and female rainbow trout ( Oncorhynchus mykiss). Fish were exposed by intraperitoneal injection to different doses of 4-NP (1, 10, 50, and 100 μg g−1) or vehicle (coconut oil) over a period of 14 days. Blood samples were collected 7 and 14 days after initiation of treatment. Plasma VTG levels in 4-NP-treated fish were detected by sodium dodecyl sulfate polyacrylamide gel electrophoresis as a high molecular weight protein band of 180 KDa. In addition, plasma VTG concentrations were quantified indirectly using plasma alkali-labile phosphate (ALP) and plasma calcium. Both ALP and calcium levels in plasma showed similar and parallel increase patterns after exposure to 4-NP that were significantly higher compared with controls. The analysis of plasma sex steroid levels revealed a significant increase in 17β-estradiol and testosterone in plasma of juvenile males and females, respectively. Furthermore, a significant increase was observed in plasma cortisol levels. On the other hand, 4-NP decreased both plasma triiodothyronine and thyroxine after 7 and 14 days of treatment. These results suggest that 4-NP can affect different parts of the endocrine system, which may lead to serious impairments in physiological homeostasis of juvenile rainbow trout.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

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