Oral Versus Vaginal Combined Hormonal Contraceptives' Effect on Coagulation and Inflammatory Biomarkers Among Young Adult Women-Reference-Cited by-同舟云学术

Oral Versus Vaginal Combined Hormonal Contraceptives' Effect on Coagulation and Inflammatory Biomarkers Among Young Adult Women

Published:2012-03-19 Issue:5 Volume:18 Page:487-494
ISSN:1076-0296
Container-title:Clinical and Applied Thrombosis/Hemostasis
language:en
Short-container-title:Clin Appl Thromb Hemost

Author:

Divani Afshin A.¹,Luo Xianghua²,Brandy Kyle R.¹,Meyer Rachel M.¹,Joseph Marilyn S.³,Flaherty James D.⁴,Rao Gundu H. R.⁵,Datta Yvonne H.⁶

Affiliation:

1. Department of Neurology, University of Minnesota, Minneapolis, MN, USA

2. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA

3. Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, MN, USA

4. Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

5. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA

6. Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, USA

Abstract

In order to compare the effect of combined oral contraceptive (COC) and combined vaginal contraceptive (CVC) methods on the inflammation and procoagulation, we recruited female participants in 3 groups: control participants, COC users, and CVC users. We measured different blood biomarkers. The users of both COC and CVC had higher levels of C-reactive protein ( P < .0001) and factor VII ( P < .0001). However, CD40 ligand was only higher for COC users ( P < .0001) and not the CVC users. Even though the levels of thrombin/antithrombin III were not higher for COC and CVC users, as compared to the controls, CVC users had higher levels as compared to COC users ( P = .0327). As compared to the control group, we observed higher levels von Willebrand factor among CVC users but not the COC users. Longitudinal studies with larger sample size are needed to better assess the inflammatory and procoagulation response due to CVC use.

Publisher

SAGE Publications

Subject

Hematology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1076029612440036

Reference41 articles.

1. Contraception for women: an evidence based overview

2. Combined oral contraceptives, smoking, and cardiovascular risk

3. Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) Study

4. Oral contraceptives, hormone therapy and cardiovascular risk

5. Female Hormones and Thrombosis

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