Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study

Author:

Pedersen Malene Roland123ORCID,Sloth Osther Palle Jørn23,Nissen Henrik Dahl4,Vedsted Peter56,Møller Henrik57,Rafaelsen Søren Rafael13

Affiliation:

1. Department of Radiology, Clinical Cancer Centre, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark

2. Urological Research Centre, Clinical Cancer Centre, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark

3. Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

4. Department of Oncology, Clinical Cancer Centre, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark

5. Research Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark

6. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

7. Cancer Epidemiology and Population Health, King’s College London, London, UK

Abstract

Background Ultrasound elastography is increasingly available in clinical practice. Recent studies showed higher velocity stiffness in testicular tumors compared to normal testicles. Purpose To evaluate ultrasound elastography in combination with the apparent diffusion coefficient measurements in diffusion weighted (DW) magnetic resonance imaging (MRI) in testicles. DW can be a useful tool in evaluating testicular malignancies. However, the relationship between velocity stiffness and MRI diffusion is not well established. Material and Methods We prospectively included 132 patients with testicular microlithiasis (n = 53), or normal testicular tissue (n = 53), or suspected for testicular cancer (n = 26). All 132 patients underwent ultrasonography including shear wave elastography and MRI diffusion coefficient examination of the scrotum. Results No clinically relevant difference in velocity stiffness was found between normal and testicles with microlithiasis. There was a significant difference in stiffness between patients with testicular microlithiasis (0.78 m/s), normal testicular tissue (0.77 m/s), and patients with testicular cancer (1.95 m/s) ( P ≤ 0.001). Similarly, there was a statistically significant difference in MRI diffusion values between patients with testicular microlithiasis (0.978 × 10−3 mm2 s−1), normal testicular tissue (0.929 × 10−3 mm2 s−1), and testicular cancers (0.743 × 10−3 mm2 s−1) ( P < 0.01). Conclusion Patients with testicular microlithiasis had no malignant characteristics measured with shear wave elastography or MRI diffusion. MRI diffusion and elastography may be useful to preoperatively differentiate benign from malignant testicular lesions.

Funder

The region of Southern Denmark and the Council of Radiographers supported this study

Publisher

SAGE Publications

Subject

Radiology Nuclear Medicine and imaging,General Medicine,Radiological and Ultrasound Technology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3