A simple prognostic score for COVID-19 hospitalized patients developing deep vein thrombosis

Author:

Bozzani Antonio1ORCID,Arici Vittorio1,Tavazzi Guido23,Boschini Stefano1,Guglielmi Angelo2ORCID,Mazza Giovanni2,Mojoli Francesco23,Bruno Raffaele34,Ragni Franco1,Sterpetti Antonio V5

Affiliation:

1. Vascular and Endovascular Surgery Unit,Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

2. Anesthesiology and Intensive Care Unit,Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

3. Department of Medical, Surgical, Diagnostic and Pediatric Science, University of Pavia, Pavia, Italy

4. Infectious Diseases Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

5. The Sapienza University of Rome, Roma, Italy

Abstract

Objective The aim of our study was to analyze the specificity, accuracy and sensitivity of a simple, easy to calculate, prognostic score for hospitalized COVID19 patients developing deep vein thrombosis. Methods From March 1st to April 28th, 942 COVID-19 patients with severe symptoms were admitted to the hospital San Matteo of Pavia-Italy. Thirty two patients (3.4%) developed deep vein thrombosis during hospitalization. In all patients hemostatic and inflammatory parameters were abnormal. A simple prognostic score was developed based on the presence of specific co morbidities and D-dimers levels (quick San Matthew Score-quick SMS): Results Nine patients died in a condition of multiple organ failure, 23 patients (71.9%) survived and left the hospital in good general conditions. The developed score was based simply on two parameters: 1) presence of four specific co morbidities and 2)systemic levels of D-Dimers. The quick San Matthew Score resulted in a sensitivity, specificity and overall accuracy of more than 90% (94%, 92%,93% respectively) and compared favorably with other scores. The score was prospectively validated in 100 COVID19 patients who developed deep vein thrombosis collected from the literature and prospectively confirmed in our hospital. Conclusions The findings of our study underline the importance of an immediate aggressive therapeutic approach for moderate and high-risk patients with COVID19 infection. The quick SMS score may help to identify patients at high risk for mortality and to follow the clinical outcome of the patient. A simple, easy to calculate prognostic score may also facilitate communication among health workers.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3