Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease-Reference-Cited by-同舟云学术

Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease

Published:2024-05-15 Issue: Volume: Page:
ISSN:0091-4150
Container-title:The International Journal of Aging and Human Development
language:en
Short-container-title:Int J Aging Hum Dev

Author:

Ahmadi Nargis¹^ORCID,Dratva Melanie A²,Heyworth Nadine²,Wang Xin²,Blennow Kaj³⁴⁵⁶,Banks Sarah J.²⁷,Sudermann Erin E.⁷

Affiliation:

1. University of California, San Diego, USA

2. Department of Neurosciences, University of California, San Diego, USA

3. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden

4. Clinical Neurochemistry Lab, Sahlgrenska University Hospital, Mölndal, Sweden

5. Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France

6. Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, P.R. China

7. Department of Psychiatry, University of California, San Diego, USA

Abstract

We examined how symptoms across the mood spectrum relate to Alzheimer's disease (AD) biomarkers in older women at high risk for AD. Participants included 25 women aged 65+ with mild cognitive deficits and elevated AD genetic risk. The Profile of Mood States Questionnaire measured mood symptoms and a total mood disturbance (TMD) score. Tau burden in the meta-temporal region of interest was measured using MK-6240 Tau positron emission tomography (PET) imaging. A subset ( n = 12) also had p-Tau181, and Aß40/42 levels measured in plasma. Higher TMD scores related to higher tau PET standardized uptake value ratio (SUVR). Greater negative mood symptoms correlated with higher tau PET SUVR, while greater vigor correlated with lower SUVR. Similar results were seen with plasma p-Tau181 levels, but not with Aβ40/42 levels. In conclusion, positive and negative mood symptoms related to tau pathology in older women at high risk for AD, highlighting a role of mental well-being in AD risk.

Funder

National Institute on Aging

California Department of Public Health, Chronic Disease Control Branch, Alzheimer’s Disease Program

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/00914150241253257

Reference52 articles.

1. Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies

2. Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

3. Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels

4. Depression is Associated with Tau and Not Amyloid Positron Emission Tomography in Cognitively Normal Adults