Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

Published:2022-05-03 Issue:1 Volume:87 Page:141-148
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Babulal Ganesh M.¹²³⁴,Chen Ling⁵,Doherty Jason M.¹,Murphy Samantha A.¹,Johnson Ann M.⁶,Roe Catherine M.¹

Affiliation:

1. Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA

2. Institute of Public Health, Washington University in St. Louis, St. Louis, MO, USA

3. Department of Psychology, Faculty of Humanities, University of Johannesburg, Johannesburg, South Africa

4. Department of Clinical Research and Leadership, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA

5. Division of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA

6. Center for Clinical Studies, Washington University in St. Louis, St. Louis, MO, USA

Abstract

Alzheimer’s disease (AD) studies in cognitively normal (CN) older adults age≥65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (Aβ42/Aβ40, t-Tau/Aβ42, p-Tau/Aβ42) predicted changes in non-depressed mood states in CN older adults (N = 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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