A new protocol for synthesizing diarylmethanes using a benzyltitanium reagent as a nucleophile-Reference-Cited by-同舟云学术

A new protocol for synthesizing diarylmethanes using a benzyltitanium reagent as a nucleophile

Published:2022-03 Issue:2 Volume:46 Page:174751982210919
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Zhang He¹^ORCID

Affiliation:

1. Department of Chemical and Environmental Engineering, Hebei Chemical and Pharmaceutical College, Shijiazhuang, People’s Republic of China

Abstract

The first palladium-catalyzed cross-coupling of various substituted benzyltitaniums with aryl triflates is presented for the synthesis of diarylmethanes in yields of up to 94% through highly selective C–O bond functionalization. The benzyltitaniums act as nucleophiles to realize the C(sp2)–C(sp3) cross-coupling with high efficiency in short reaction times. The reactions proceed at 60°C and show excellent functional groups tolerance.

Funder

Hebei Chemical & Pharmaceutical College

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/17475198221091941

Reference51 articles.

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5. Synthesis of Functionalized Diarylmethanes via a Copper-Catalyzed Cross-Coupling of Arylmagnesium Reagents with Benzylic Phosphates

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