Electroacupuncture ameliorates senile osteoporosis by promoting bone remodeling and regulating autophagy-Reference-Cited by-同舟云学术

Electroacupuncture ameliorates senile osteoporosis by promoting bone remodeling and regulating autophagy

Published:2024-07-28 Issue: Volume: Page:
ISSN:0964-5284
Container-title:Acupuncture in Medicine
language:en
Short-container-title:Acupunct Med

Author:

Liu Jing¹²³^ORCID,Zhou Jun¹²³,Wang Jinlin¹²³,Huang Xiarong¹²³,Qu Mengjian¹²³,Liao Ying¹²³,Sun Guanghua¹²³,Zhong Peirui¹²³,Tan Jinqu¹²³,Sun Zhilu⁴

Affiliation:

1. The First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, China

2. The First Affiliated Hospital, Department of Rehabilitation, Hengyang Medical School, University of South China, Hengyang, China

3. The First Affiliated Hospital, Rehabilitation Laboratory, Hengyang Medical School, University of South China, Hengyang, China

4. The First Affiliated Hospital, Department of Emergency, Hengyang Medical School, University of South China, Hengyang, China

Abstract

Objectives: Osteoporosis is widely regarded as a typical aged-related disease caused by impaired bone remodeling. This research was designed to explore the protective effects of electroacupuncture (EA) on senile osteoporosis in a rat model and investigate the underlying mechanisms. Methods: Three-month-old rats were randomly selected as the youth group, and 24-month-old rats were randomly assigned to the elderly and EA groups. Rats in the EA group received 30 min of EA at bilateral SP10, ST36, K13 and GB34 daily, 5 days a week for 8 weeks. Bone mineral density (BMD), microstructure of the bone tissue, bone turnover biomarkers and expression level of autophagy-related proteins were detected. Results: Compared with the elderly group, EA treatment significantly increased BMD of the femur and ameliorated the microstructure. EA treatment increased trabecular bone volume ratio (= bone volume / total volume [BV/TV]) and trabecular number (Tb.N) and decreased trabecular separation (Tb.Sp) in senile osteoporosis rats. Compared with the elderly group, the serum N-terminal telopeptide of type I collagen (NTX1) level in the EA group was lower, and the serum procollagen type I N-terminal propeptide (PINP) concentration was higher. In addition, the expression of Beclin 1, microtubule-associated protein I light chain 3 (LC3B) and P62 was inhibited in the senile osteoporosis rats after EA treatment. Conclusions: EA can effectively alleviate aging-related bone loss and improve the microstructure of bone tissue in senile osteoporosis rats, and the regulation of autophagy might be one of the important mechanisms.

Funder

the Clinical medical technology innovation guide project of Hunan province

Natural Science Foundation of Hunan Province

National Natural Science Foundation of China

the Science and technology Project of Hunan Provincial Health Commission

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/09645284241265872

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