Electroacupuncture stimulation at BL20, BL23 and SP6 prevents hind limb unloading–induced osteoporosis in rats

Author:

Wang Honghui12ORCID,Wang Desheng1,Li Zhili1,Liu Shujuan1,Dong Jingjing23,Zhang Jianfeng1,Wang Huijuan1,Wang Minjie4,Ji Bo5,Li Yinghui1

Affiliation:

1. State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China

2. The Key Laboratory of Aerospace Medicine, Ministry of Education, Air Force Medical University, Xi’an, China

3. Lintong Aeromedical Evaluation and Training Center, Xi’an, China

4. Beijing Jingmei Group General Hospital, Beijing, China

5. School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China

Abstract

Background: Bone loss induced by microgravity is a serious problem in space flight. However, the effects of acupuncture stimulation on osteoporosis induced by microgravity have not been studied. With the goal of developing an effective countermeasure, our aim was to evaluate the effects of electroacupuncture (EA) stimulation at BL20, BL23, and SP6 on osteoporosis induced by simulated microgravity in rats. Methods: Thirty male Wistar rats (aged 10 weeks) were randomly divided into three groups: healthy control group (CON, n = 10), hind limb unloading by tail-suspension group (T-S, n = 10), and EA treatment group (TRE, n = 10). Rats in the T-S and TRE groups were subjected to tail-suspension at −30° for 30 days, while the CON group experienced freedom of activity. In this period, the TRE group received EA treatment at BL20, BL23, and SP6 for 30 min every other day, which continued for 30 days. The microarchitecture of the proximal tibia and the biomechanical features of the femur in the rats were analyzed. In addition, the levels of serum biomarkers bone alkaline phosphatase (BALP) and osteocalcin (BGP) were measured. Results: Compared with the CON group, the value of bone volume/total volume (BV/TV) and trabecular number (Tb.N) of the tibias in the TRE group remarkably decreased ( p  < 0.01). However, these changes were markedly less than those of the T-S group after 4 weeks of EA treatment ( p  < 0.05). Moreover, the serum concentration of BGP in the TRE group was also significantly higher than that of the T-S group ( p  < 0.05). Conclusions: These findings indicate that EA stimulation at BL20, BL23, and SP6 retards osteoporosis induced by hind limb unloading in rats.

Funder

the Advanced Space Medical Research Project of China

state key laboratory of space medicine fundamentals and application, china astronaut research and training center

National Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Clinical Neurology,Complementary and alternative medicine,General Medicine

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