Fertility and Pregnancy-Related Issues in Young <i>BRCA</i> Carriers With Breast Cancer-Reference-Cited by-同舟云学术

Fertility and Pregnancy-Related Issues in Young BRCA Carriers With Breast Cancer

Published:2024-01 Issue: Volume:18 Page:
ISSN:1178-2234
Container-title:Breast Cancer: Basic and Clinical Research
language:en
Short-container-title:Breast Cancer�(Auckl)

Author:

Magaton Isotta Martha¹²,Arecco Luca³,Mariamidze Elene²⁴,Jankovic Kristina⁵,Stana Mihaela⁶,Buzzatti Giulia⁷,Trevisan Lucia⁷,Scavone Graziana²,Ottonello Silvia⁸,Fregatti Piero⁹¹⁰,Massarotti Claudia¹¹¹²,von Wolff Michael¹,Lambertini Matteo²³

Affiliation:

1. Division of Gynaecological Endocrinology and Reproductive Medicine, University Women’s Hospital, Inselspital, Bern, Switzerland

2. Department of Medical Oncology, U.O.C. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

3. Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genoa, Genoa, Italy

4. Department of Medical Oncology & Hematology, Todua Clinic, Tbilisi, Georgien

5. Department of Medical Oncology, University Clinic Center Nis, Nis, Serbia

6. Department of Medical Oncology, Elysee Hospital, Alba Iulia, Romania

7. Department of Medical Oncology, Unit of Hereditary Cancer, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

8. Departent of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy

9. Department of Surgery, U.O.C. Clinica di Chirurgia Senologica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

10. Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, Genoa, Italy

11. Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health (DINOGMI Department), University of Genoa, Genoa, Italy

12. Academic Unit of Obstetrics and Gynecology, Maternal-Child Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

Abstract

Approximately 10% to 15% of breast cancer cases in young women are diagnosed in patients harbouring germline (g) pathogenic or likely pathogenic variants (PVs) in the BReast CAncer 1 ( BRCA1) or BReast CAncer 2 ( BRCA2) genes. Preclinical and clinical studies showed a potential negative effect of germline BRCA1/2 (g BRCA1/2) PVs on ovarian reserve and reproductive potential, even before starting anticancer therapies. The aim of this article is to summarize the current literature on the fertility potential of young g BRCA1/2 PVs carriers with breast cancer and the risk of gonadotoxicity associated with anticancer treatments. Moreover, we describe the available evidence on the efficacy of fertility preservation techniques in young g BRCA1/2 PVs carriers and the safety data on having a pregnancy after breast cancer treatment.

Funder

Associazione Italiana per la Ricerca sul Cancro, AIRC

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/11782234241261429

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