Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Author:

Kuchenbaecker Karoline B.1,Hopper John L.2,Barnes Daniel R.3,Phillips Kelly-Anne4,Mooij Thea M.5,Roos-Blom Marie-José6,Jervis Sarah7,van Leeuwen Flora E.5,Milne Roger L.8,Andrieu Nadine9,Goldgar David E.10,Terry Mary Beth11,Rookus Matti A.5,Easton Douglas F.3,Antoniou Antonis C.3,McGuffog Lesley3,Evans D. Gareth12,Barrowdale Daniel3,Frost Debra3,Adlard Julian13,Ong Kai-ren14,Izatt Louise15,Tischkowitz Marc16,Eeles Ros17,Davidson Rosemarie18,Hodgson Shirley19,Ellis Steve3,Nogues Catherine20,Lasset Christine21,Stoppa-Lyonnet Dominique22,Fricker Jean-Pierre23,Faivre Laurence24,Berthet Pascaline25,Hooning Maartje J.26,van der Kolk Lizet E.27,Kets Carolien M.28,Adank Muriel A.29,John Esther M.30,Chung Wendy K.31,Andrulis Irene L.32,Southey Melissa33,Daly Mary B.34,Buys Saundra S.35,Osorio Ana36,Engel Christoph37,Kast Karin38,Schmutzler Rita K.39,Caldes Trinidad40,Jakubowska Anna41,Simard Jacques42,Friedlander Michael L.43,McLachlan Sue-Anne44,Machackova Eva45,Foretova Lenka45,Tan Yen Y.46,Singer Christian F.47,Olah Edith48,Gerdes Anne-Marie49,Arver Brita50,Olsson Håkan51,

Affiliation:

1. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England

2. Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, University of Melbourne, Melbourne, Australia

3. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England

4. Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, University of Melbourne, Melbourne, Australia4Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia5Department of Medicine, St Vincent’s Hospital, University of Melbourne, Parkville, Australia6Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia

5. Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands

6. Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands8Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

7. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England9Mathematics Institute, University of Warwick, Coventry, England

8. Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, University of Melbourne, Melbourne, Australia10Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia

9. Inserm U900, Paris, France12Institut Curie, Paris, France13Mines ParisTech, Fontainebleau, France14PSL Research University, Paris, France

10. Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah

11. Department of Epidemiology, Columbia University, New York, New York

12. Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, England

13. Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, England

14. West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Birmingham, England

15. Clinical Genetics, Guy’s and St Thomas’ NHS Foundation Trust, London, England

16. Department of Medical Genetics and National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, England

17. Oncogenetics Team, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, England

18. Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, Scotland

19. Department of Clinical Genetics, St George’s, University of London, London, England

20. Oncogénétique Clinique, Hôpital René Huguenin/Institut Curie, Saint-Cloud, France

21. Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France

22. Institut Curie, Department of Tumour Biology, Paris, France28Institut Curie, INSERM U830, Paris, France29Université Paris Descartes, Sorbonne Paris Cité, Paris, France

23. Unité d’Oncogénétique, Centre Paul Strauss, Strasbourg, France

24. Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France32Centre de Génétique, Hôpital d’Enfants, CHU Dijon, Dijon, France

25. Centre François Baclesse, Caen, France

26. Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands

27. Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands

28. Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands

29. Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands

30. Department of Epidemiology, Cancer Prevention Institute of California, Fremont

31. Departments of Pedicatrics and Medicine, Columbia University, New York, New York

32. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada41Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

33. Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia

34. Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania

35. Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah

36. Human Genetics Group, Spanish National Cancer Centre, Madrid, Spain46Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain

37. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany48LIFE–Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany

38. Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Dresden, Germany50National Center for Tumor Diseases, Partner Site Dresden, Dresden, Germany51German Cancer Consortium, Dresden and German Cancer Research Center, Heidelberg, Germany

39. Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany

40. Molecular Oncology Laboratory, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos, Madrid, Spain

41. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

42. Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Québec City, Québec, Canada

43. Prince of Wales Clinical School, University of New South Wales, Sydney, Australia57Department of Medical Oncology, Prince of Wales Hospital, Randwick, Australia

44. Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia58Department of Medical Oncology, St Vincent’s Hospital, Fitzroy, Australia

45. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic

46. Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria61QIMR Berghofer Medical Research Institute, Herston, Australia

47. Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria

48. Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary

49. Department of Clinical Genetics, Copenhagen University Hospital Rigshospital, Copenhagen, Denmark

50. Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden

51. Department of Oncology, Lund University Hospital, Lund, Sweden

Publisher

American Medical Association (AMA)

Subject

General Medicine

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