Therapeutic Potential of Selenium and Selenium Compounds in Cervical Cancer

Author:

Jablonska Ewa1ORCID,Li Qi2,Reszka Edyta1ORCID,Wieczorek Edyta1,Tarhonska Kateryna1ORCID,Wang Tong3

Affiliation:

1. Department of Translational Research, Nofer Institute of Occupational Medicine, Lodz, Poland

2. Department of Gynecological Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, China

3. Harbin Medical University, Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China

Abstract

Cervical cancer is a common female cancer. It is strongly associated with human papillomavirus (HPV) infection. However, HPV infection alone is not sufficient to induce cervical cancer because its development is dependent on the coexistence of several factors that enable the virus to overcome the host immune system. These include individual genetic background, environmental factors, or diet, including dietary selenium intake. Selenium is an essential trace element with antiviral properties and has been shown to exert antitumor effects. Surprisingly, the role of selenium in cervical cancer has not been studied as intensively as in other cancers. Here, we have summarized the existing experimental data on selenium and cervical cancer. It may be helpful in evaluating the role of this nutrient in treatment of the mentioned malignancy as well as in planning further studies in this area.

Funder

China Postdoctoral Science Foundation

Publisher

SAGE Publications

Subject

Oncology,Hematology,General Medicine

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