Why Opioids and Sedatives May Prolong Life Rather Than Hasten Death After Ventilator Withdrawal in Critically Ill Patients-Reference-Cited by-同舟云学术

Why Opioids and Sedatives May Prolong Life Rather Than Hasten Death After Ventilator Withdrawal in Critically Ill Patients

Published:2008-01-15 Issue:2 Volume:25 Page:152-154
ISSN:1049-9091
Container-title:American Journal of Hospice and Palliative Medicine®
language:en
Short-container-title:Am J Hosp Palliat Care

Author:

Bakker Jan¹,Jansen Tim C.²,Lima Alex²,Kompanje Erwin J. O.²

Affiliation:

1. Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands,

2. Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands

Abstract

The process of death in patients in whom cardiorespiratory support is withdrawn is related to the occurrence of tissue hypoxia that results from an imbalance between the demand for oxygen and the delivery of oxygen to the organs. Limiting the demand for oxygen may thus delay the occurrence of tissue hypoxia. Because the demand for oxygen increases significantly after ventilator withdrawal and because sedatives and opioids are known to decrease the demand for oxygen in patients with cardiorespiratory distress, these agents might thus actually prolong life rather than hasten death.

Publisher

SAGE Publications

Subject

General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1049909108315511

Reference11 articles.

1. Opioids and Benzodiazepines Appear Paradoxically to Delay Inevitable Death after Ventilator Withdrawal

2. Care for the dying in intensive care in The Netherlands

3. Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia

4. Identification of the Critical Oxygen Delivery for Anaerobic Metabolism in Critically III Septic and Nonseptic Humans

5. Critical O2 transport values at lowered body temperatures in rats

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