“Misura” Project: A Retrospective Survey on the Use of 5fluorouracil in the Treatment of Colorectal Cancer in 24 Italian Clinical Centers

Author:

Poletti Paola1,Pinotti Graziella2,Rosati Gerardo3,Luppi Gabriele4,Ibrahim Toni5,Marinozzi Claudio6,Pucci Francesca7,Pancera Gianfranco8,Biasco Guido9,Barni Sandro10,Garufi Carlo11,Martignoni Giancarlo12,Visonà Giovanni13,Labianca Roberto1

Affiliation:

1. Unità Operativa di Oncologia Medica, Ospedali Riuniti, Bergamo;

2. Unità Operativa di Oncologia Medica, Ospedale di Circolo, Varese;

3. Unità Operativa di Oncologia Medica, Ospedale S Carlo, Potenza;

4. Unità Operativa di Oncologia Medica, Policlinico di Modena;

5. Unità Operativa di Oncologia Medica, Ospedale L Pierantoni, Forlì;

6. Unità Operativa di Oncologia Medica, Policlinico Umberto I, Rome;

7. Unità Operativa di Oncologia Medica, Azienda Ospedaliera, Parma;

8. Unità Operativa di Oncologia Medica, Clinica IGEA, Milan;

9. Unità Operativa di Oncologia Medica, Ospedale Sorsola, Bologna;

10. Unità Operativa di Oncologia Medica, Ospedale S Gerardo, Monza;

11. Unità Operativa di Oncologia Medica, Ospedale Regina Elena, Rome;

12. Unità Operativa di Oncologia Medica, Ospedale S Carlo, Milan;

13. Glaxo-Wellcome, Verona

Abstract

The “Misura” project is a retrospective survey, with the aim to evaluate how 5FU is used in the treatment of colorectal cancer in clinical practice in Italian oncology departments. Twenty-four centers participated. Patients seen in the second half of 1998 with colorectal cancer and treated with 5FU were analyzed. Observed patients were 664, 45.9% of patients presented metastatic disease. Biochemical modulation with folinic acid and bolus 5FU was the most used schedule (59%). The De Gramont (LV 5FU2) regimen, alone or with other cytotoxic drugs, was the second most chosen schedule (14%). The most frequent side effect observed was gastrointestinal toxicity. No hematological toxicity was demonstrated in 68.8% of patients. Cutaneous toxicity occurred in 21.1% of patients. 5FU is widely used independently by the stage of disease. In palliative treatment a variety of schedules were administered by the Italian centers, lacking a standard therapy. There are very few surveys investigating oncology clinical practice. A larger survey on this issue is auspicable.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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