HLA-Dr Expression by Tumor Cells Compared with Survival in High Grade Astrocytomas-Reference-Cited by-同舟云学术

HLA-Dr Expression by Tumor Cells Compared with Survival in High Grade Astrocytomas

Published:1991-04 Issue:2 Volume:77 Page:122-125
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Rossi Marco L.¹,Jones Nigel R.¹,Karr George F.²,Esiri Margaret M.¹,Havas Laszlo¹,Coakham Hugh B.³

Affiliation:

1. Dept of Neuropathology and Neurosurgery, Frenchay Hospital, Bristol

2. Radcliffe Infirmary, Oxford, Frenchay Hospital, Bristol

3. Brain Tumor Research Lab., Dept of Neurosurgery, Frenchay Hospital, Bristol

Abstract

Frozen samples from 78 high grade astrocytomas were reacted with a monoclonal antibody directed against HLA-Dr invariant chain. Survival data was obtained for all 78 cases. HLA-Dr was expressed by a proportion of tumor cells in 65/78 (83 %). Comparison of the survival of positive and negative cases showed that the difference was not statistically significant (p = 0.4). The relevance of the finding is discussed in the context of the immunoreaction to brain tumors.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030089169107700206

Reference42 articles.

1. Cellular Detection of HLA Class II-Encoded Determinants: Subtype Polymorphisms of HLA-D

2. Transplantation Immunology

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