Affiliation:
1. Toxicology Department-Indianapolis Center, Marion Merrell Dow Inc., P.O. Box 68470, Indianapolis, Indiana 46268-0470
2. Biostatistics Department-Cincinnati Center, Marion Merrell Dow Inc., P.O. Box 156300, Cincinnati, Ohio 45215-6300
Abstract
The carcinogenic potential of prednisone, a synthetic corticosteroid used as an anti-inflammatory and immunosuppressive agent, was investigated by feeding it to Cr1:CD-1(ICR) mice (50/sex/dose) at doses of 0.25, 0.50, 1.0, and 5.0 mg/kg/day for 18 months. Prednisone did not significantly increase the incidence of neoplasms ( p ≤ 0.05); on the contrary, it significantly decreased the incidence of hepatocellular tumors (p = 0.002 in males, p = 0.027 in females), male lacrimal/Harderian gland tumors ( p = 0.05), female pulmonary adenomas (p = 0.047), female endothelial cell tumors (p = 0.035), and female lymphosarcomas ( p = 0.02). This study suggests that long-term (lifetime) prednisone use does not increase cancer risk and may actually reduce it.
Subject
Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine
Cited by
12 articles.
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