Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Published:2020-01-02 Issue:1 Volume:135 Page:41-55
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li Benshang¹²,Brady Samuel W.³,Ma Xiaotu³,Shen Shuhong¹²,Zhang Yingchi⁴,Li Yongjin³,Szlachta Karol³,Dong Li³,Liu Yu³,Yang Fan¹²,Wang Ningling⁵,Flasch Diane A.³^ORCID,Myers Matthew A.⁶^ORCID,Mulder Heather L.³,Ding Lixia¹²,Liu Yanling³,Tian Liqing³,Hagiwara Kohei³,Xu Ke³^ORCID,Zhou Xin³,Sioson Edgar³^ORCID,Wang Tianyi¹,Yang Liu¹,Zhao Jie¹,Zhang Hui⁷,Shao Ying³,Sun Hongye⁸,Sun Lele⁸,Cai Jiaoyang¹,Sun Hui-Ying¹,Lin Ting-Nien⁹,Du Lijuan¹²,Li Hui¹²^ORCID,Rusch Michael³,Edmonson Michael N.³^ORCID,Easton John³^ORCID,Zhu Xiaofan⁴,Zhang Jingliao⁴^ORCID,Cheng Cheng¹⁰,Raphael Benjamin J.⁶,Tang Jingyan¹,Downing James R.¹¹,Alexandrov Ludmil B.¹²,Zhou Bin-Bing S.¹²,Pui Ching-Hon¹³^ORCID,Yang Jun J.⁹,Zhang Jinghui³^ORCID

Affiliation:

1. Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Children’s Medical Center—National Children’s Medical Center, and

2. Pediatric Translational Medicine Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

3. Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN;

4. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital—Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China;

5. Department of Pediatrics, the Second Hospital of Anhui Medical University, Hefei, China;

6. Department of Computer Science, Princeton University, Princeton, NJ;

7. Department of Pediatric Hematology/Oncology, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, China;

8. WuXi NextCODE Co., Ltd, Shanghai, China;

9. Department of Pharmaceutical Sciences,

10. Department of Biostatistics, and

11. Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, TN;

12. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA; and

13. Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

Abstract

Li and colleagues report the genomic landscape of over 100 patients with relapsed acute lymphoblastic leukemia. Analysis of diagnosis-relapse-remission trios suggest that whereas early relapse is mediated by retained subclones, late relapse is driven by mutations induced by and conferring resistance to chemotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/135/1/41/1550427/bloodbld2019002220.pdf

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5. Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL;Li;Nat Med,2015

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