Immunosuppression Profile of CFZ533 (Iscalimab), a Non-Depleting Anti-CD40 Antibody, and the Presence of Opportunistic Infections in a Rhesus Monkey Toxicology Study
Author:
Affiliation:
1. Novartis Institutes for Biomedical Research, Basel, Switzerland
2. Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
3. Roche, Basel, Switzerland
Abstract
Publisher
SAGE Publications
Subject
Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine
Link
http://journals.sagepub.com/doi/pdf/10.1177/01926233221100168
Reference57 articles.
1. A Novel, Blocking, Fc-Silent Anti-CD40 Monoclonal Antibody Prolongs Nonhuman Primate Renal Allograft Survival in the Absence of B Cell Depletion
2. Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non-depleting anti-CD40 monoclonal antibody
3. Nonclinical Safety Assessment of CFZ533, a Fc-Silent Anti-CD40 Antibody, in Cynomolgus Monkeys
4. CD40/CD40L signaling and its implication in health and disease
5. Epithelial cells as immune effector cells: The role of CD40
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1. Combination of Anti-CD40 and Anti-CD40L Antibodies as Co-Stimulation Blockade in Preclinical Cardiac Xenotransplantation;Biomedicines;2024-08-22
2. Iscalimab Combined With Transient Tesidolumab Prolongs Survival in Pig‐to‐Rhesus Monkey Renal Xenografts;Xenotransplantation;2024-07
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