HYPERTROPHY OF THE AGRANULAR ENDOPLASMIC RETICULUM IN HAMSTER LIVER INDUCED BY PHENOBARBITAL (WITH A REVIEW ON THE FUNCTIONS OF THIS ORGANELLE IN LIVER)

Author:

JONES A. L.1,FAWCETT D. W.1

Affiliation:

1. Department of Anatomy, Harvard Medical School, Boston, Massachusetts

Abstract

The electron microscopic appearance of normal hamster liver is illustrated, and attention is drawn to certain unusual features of hepatocyte fine structure that have not hitherto been described. Examination of liver cells from animals receiving repeated intraperitoneal injections of phenobarbital, reveals a spectacular hypertrophy of the agranular reticulum and a depletion of particulate glycogen. The increase in smooth endoplasmic reticulum cannot be explained by loss of ribosomes from the granular reticulum and is regarded as an absolute gain of new membrane. Numerous examples of continuity between granular and agranular reticulum are observed, and it is suggested that protein synthesis associated with the granular reticulum contributes to the formation of the new smooth-surfaced membranes. In discussing the morphological alterations of the liver induced by phenobarbital, numerous biochemical changes reported in the literature have been reviewed in an effort to gain a clearer view of the over-all significance of the agranular reticulum in liver cell function. The evidence points to an important role in hydroxylation and elimination of lipid-soluble drugs, and in cholesterol and steroid hormone metabolism. There are indications that it also plays some role in carbohydrate metabolism, but the exact nature of its participation cannot yet be defined.

Publisher

SAGE Publications

Subject

Histology,Anatomy

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3