A Combination of Poor Adherence and a Low Baseline Susceptibility Score is Highly Predictive for HAART Failure-Reference-Cited by-同舟云学术

A Combination of Poor Adherence and a Low Baseline Susceptibility Score is Highly Predictive for HAART Failure

Published:2002-08 Issue:4 Volume:13 Page:231-240
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Van Vaerenbergh Kristien¹,De Geest Sabina¹²,Derdelinckx Inge¹,Bobbaers Herman¹,Carbonez An³,Deschamps Ann¹,De Graeve Veerle¹,De Saar Veerle¹,Ceunen Helga¹,De Smet Koen⁴,Maes Bart¹,Peetermans Willy¹,Schrooten Yoeri¹,Desmyter Jan¹,De Clercq Erik¹,Van Ranst Marc¹,Van Wijngaerden Eric¹,Vandamme Anne-Mieke¹

Affiliation:

1. Rega Institute and University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium

2. University of Basel, Switzerland

3. Universitair Centrum voor Statistiek, Katholieke Universiteit Leuven, Leuven, Belgium

4. Innogenetics NV, Gent, Belgium

Abstract

The relationship between adherence, virological response to highly active antiretroviral therapy (HAART) and the presence and development of genotypic resistance was assessed in 41 HIV-infected patients on HAART. Four adherence parameters (drug taking adherence, dosing adherence, timing adherence and drug holidays) were scored prospectively using electronic event monitoring. Genotypic resistance at baseline and after therapy failure was scored retrospectively and a genotype-based susceptibility score was calculated. Overall median adherence rates were high. All adherence parameters were better in virological responders ( n=31) compared to non-responders ( n=10), drug taking adherence and number of drug holidays being significantly different. Responders had a significantly higher susceptibility score. Stepwise logistic regression showed that the number of drug holidays and a low susceptibility score were highly predictive for therapy failure. Despite the presence of a limited number of baseline resistance mutations, perfectly adherent patients can control virus replication for a prolonged period.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632020201300404

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