1. Department of Intensive Care Medicine, University Hospital RWTH Aachen, Germany
2. SMITH Consortium of the German Medical Informatics Initiative, Germany
3. Juelich Supercomputing Centre, Forschungszentrum Juelich, Germany
4. Department of Anesthesiology, University Hospital RWTH Aachen, Germany
5. Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, University of Iceland, Iceland