Anticardiolipin antibodies and acute alcoholic intoxication

Abstract

Many clinical features have been associated with the antiphospholipid antibodies. In a preliminary prospective study, among 1014 consecutive patients admitted to a Medicine Department, 72 (7.1%) patients were found to be anticardiolipin antibodies (aCL) positive. Eight ( 11 %) of these aCL positive patients had alcoholic intoxication. Chronic alcoholism is known to be associated with a high prevalence of autoimmune disorders. The objective of this study was to determine the prevalence of aCL in patients with acute alcoholic intoxication. Sixty two patients (13 women; 49 men), mean age 35 years (range 17-63 years) referred to the emergency care unit were studied. A control population of 62 apparently healthy subjects, age and sex matched, were also tested. Alcoholaemia, aCL, antinuclear antibodies (ANA), Venereal Disease Research Laboratory (VDRL) and Treponema pallidum immobilisation (TPHA) were determined. The mean alcoholaemia among all patients tested was 2.35 g l-1 (range 0.1-4). aCL were found positive in 10 patients (16%); eight men and two women. Seven patients had aCL IgG level of ≥ 15 UG PL/ml while two had IgM level of ≥ 12.5 UMPL/ml. One had both elevated aCL IgG and IgM. Statistical analysis confirmed that aCL positivity is more frequently encountered in alcoholic patients compared with an age and sex matched population (P = 0.0298). Among alcoholic patients, 12 (19%) had ANA. Four of them were VDRL positive while all were TPHA negative. Two of the 62 control subjects were found aCL positive. From these data, it can be concluded that increased aCL levels are frequently associated with acute alcoholic abuse.