Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics-Reference-Cited by-同舟云学术

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Published:2021-07-14 Issue:1_suppl Volume:40 Page:5S-19S
ISSN:1091-5818
Container-title:International Journal of Toxicology
language:en
Short-container-title:Int J Toxicol

Author:

Burnett Christina L.¹,Bergfeld Wilma F.²,Belsito Donald V.²,Cohen David²,Klaassen Curtis D.²,Liebler Daniel C.²,Marks James G.³,Peterson Lisa A.²,Shank Ronald C.²,Slaga Thomas J.²,Snyder Paul W.²,Heldreth Bart⁴

Affiliation:

1. Cosmetic Ingredient Review Senior Scientific Analyst/Writer

2. Expert Panel for Cosmetic Ingredient Safety Member

3. Expert Panel for Cosmetic Ingredient Safety Former Member

4. Cosmetic Ingredient Review Executive Director

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as a preservative in cosmetics. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessments of Methylisothiazolinone, and concluded that Methylisothiazolinone is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm (ie, 0.01%) and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment or similar methodology.

Publisher

SAGE Publications

Subject

Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/10915818211015795

Reference26 articles.

1. Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

2. Final Report of the Safety Assessment of Methylisothiazolinone

3. Special aspects of cosmetic spray safety evaluations: Principles on inhalation risk assessment

4. US Environmental Protection Agency (EPA). Registration Review Draft Risk Assessment for 2-Methyl-4-Isothiazolin-3-One (MIT) and 5-Chloro-2-Methyl-4-Isothiazolin-3-One (CMIT). Published April 6, 2020. Accessed May 27, 2020. 94.

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Current frequency of contact allergy to isothiazolinones (methyl‐, benz‐ and octylisothiazolinone) across Europe;Contact Dermatitis;2024-07-17

2. Machine learning assisted rational design of antimicrobial peptides based on human endogenous proteins and their applications for cosmetic preservative system optimization;Scientific Reports;2024-01-10

3. Is Laundry Detergent a Common Cause of Allergic Contact Dermatitis?;Cutis;2023-04

4. Equilibria of semi-volatile isothiazolinones between air and glass surfaces measured by gas chromatography and Raman spectroscopy;Environmental Research;2023-02

5. Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds;Applied In Vitro Toxicology;2022-12-01