Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics-Reference-Cited by-同舟云学术

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Published:2019-05 Issue:1_suppl Volume:38 Page:70S-84S
ISSN:1091-5818
Container-title:International Journal of Toxicology
language:en
Short-container-title:Int J Toxicol

Author:

Burnett Christina L.¹,Boyer Ivan²,Bergfeld Wilma F.³,Belsito Donald V.³,Hill Ronald A.³,Klaassen Curtis D.³,Liebler Daniel C.³,Marks James G.³,Shank Ronald C.³,Slaga Thomas J.³,Snyder Paul W.³,Gill Lillian J.⁴,Heldreth Bart⁵

Affiliation:

1. Cosmetic Ingredient Review Scientific Analyst/Writer, Cosmetic Ingredient Review, Washington, DC, USA

2. Cosmetic Ingredient Review Former Toxicologist, Cosmetic Ingredient Review, Washington, DC, USA

3. Cosmetic Ingredient Review Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA

4. Cosmetic Ingredient Review Former Director, Cosmetic Ingredient Review, Washington, DC, USA

5. Cosmetic Ingredient Review Executive Director, Cosmetic Ingredient Review, Washington, DC, USA

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.

Publisher

SAGE Publications

Subject

Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1091581819838792

Reference46 articles.

1. Personal Care Products Council. February 25, 2014. Methylisothiazolinone. Unpublished data submitted by Personal Care Products Council. 8 pages.

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