Safety Assessment of Alkane Diols as Used in Cosmetics

Author:

Scott Laura N.1,Fiume Monice2,Bergfeld Wilma F.3,Belsito Donald V.3,Hill Ronald A.4,Klaassen Curtis D.3,Liebler Daniel C.4,Marks James G.4,Shank Ronald C.4,Slaga Thomas J.3,Snyder Paul W.3,Heldreth Bart5

Affiliation:

1. Cosmetic Ingredient Review Former Scientific Analyst/Writer

2. Cosmetic Ingredient Review Senior Director

3. Expert Panel for Cosmetic Ingredient Safety Member

4. Expert Panel for Cosmetic Ingredient Safety Former Member

5. Cosmetic Ingredient Review Executive Director

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 10 alkane diol ingredients as used in cosmetics. The alkane diols are structurally related to each other as small diols, and most are reported to function in cosmetics as solvents. The Panel reviewed the relevant data for these ingredients, and concluded that seven alkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety for three ingredients, namely 1,4-Butanediol, 2,3-Butanediol, and Octanediol.

Funder

Personal Care Products Council

Publisher

SAGE Publications

Subject

Toxicology

Reference115 articles.

1. U.S. Environmental Protection Agency (EPA). High Production Volume (HPV) Chemical Challenge Program for 2-Methyl-1,3-Propanediol (CAS RN 2163-42-0); 2004. Date Accessed 3-29-2016. Report No. 201-15559A:1-16. Data were submitted by Lyondell Chemical Company.

2. Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics

3. Safety Assessment of 1,2-Glycols as Used in Cosmetics

4. Final Report on the Safety Assessment of Propylene Glycol and Polypropylene Glycols

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