Pathophysiology of chronic peripheral ischemia: new perspectives-Reference-Cited by-同舟云学术

Pathophysiology of chronic peripheral ischemia: new perspectives

Published:2020-01 Issue: Volume:11 Page:204062231989446
ISSN:2040-6223
Container-title:Therapeutic Advances in Chronic Disease
language:en
Short-container-title:Therapeutic Advances in Chronic Disease

Author:

Signorelli Salvatore Santo¹^ORCID,Vanella Luca²,Abraham Nader G.³,Scuto Salvatore⁴,Marino Elisa⁴,Rocic Petra³

Affiliation:

1. Department of Clinical and Experimental Medicine, University of Catania, University Hospital ‘G. Rodolico’, Catania, 95124, Italy

2. Department of Drug Science, University of Catania, Catania, Italy

3. Departments of Medicine, Pharmacology and Gastroenterology, New York Medical College, Valhalla, NY, USA

4. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

Abstract

Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD.

Publisher

SAGE Publications

Subject

Medicine (miscellaneous)

Link

http://journals.sagepub.com/doi/pdf/10.1177/2040622319894466

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