Affiliation:
1. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, P. R. China
2. College of Pharmaceutical Science, Guilin Medical University, Guilin 541004, P. R. China
3. Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, CAS, Guangzhou 510301, P. R. China
Abstract
Chemical investigation of the fungus Aspergillus sp. SCSIO41211 derived of mangrove sediment sample afforded a ergostane-type pentacyclic steroid, (22 S, 23 R)-12α,14α,23α-trihydroxy-16,22-epoxy-ergosta-4,8-dien-3,11-dione (1), together with seven known compounds, flavacol (2), aspergilliamide (3), ochratoxin A methyl ester (4), ochratoxin A ethyl ester (5), dihydroaspyrone (6), aspilactonol E (7) and aspilactonol F (8). The structures were determined on the basis of NMR and MS analysis. The isolated compounds were tested for their antiviral activity against H3N2 and EV71 viruses, cytotoxic, and antituberculosis effects. Among them, compounds 2 and 5 showed significant cytotoxicity against ten human cancer cell lines. None of the compounds displayed a significant antiviral activity against H3N2 and EV71 viruses nor antimycobacterial activities.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Cited by
3 articles.
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