Cytotoxic Triterpenes From Trametes orientalis-Reference-Cited by-同舟云学术

Cytotoxic Triterpenes From Trametes orientalis

Published:2020-05-01 Issue:5 Volume:15 Page:1934578X2092162
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Xiao Kun-Min¹,Wang Jun-Ming¹,Zhou Ling-Yun²,Guo Lei¹,Tan Da-Cong¹,Yan Qi³,Hua Yan¹^ORCID

Affiliation:

1. Key Laboratory for Forest Resources Conservation and Use in the Southwest Mountains of China, Southwest Forestry University, Kunming, China

2. Anhui Provincial Engineering Research Center for Polysaccharide Drugs, School of Pharmacy, Wannan Medical College, Wuhu, China

3. No. 2 Neurosurgery Department, First Hospital of Kunming Medical University, China

Abstract

One new triterpene, 24-ene-2′-methyl carboxy acetylquercinicate, and 3 known compounds were isolated from the ethyl acetate extract of the fruiting bodies of Trametes orientalis (Yasuda) Imazeki. Their structures were elucidated by means of extensive spectroscopic analysis and compared with data reported in the literature. Furthermore, they were evaluated for their cytotoxicity against 5 human cancer cell lines in vitro. Compound 4 showed significant cytotoxicity, especially to the leukemic HL-60 cell line (IC50 = 1.77 ± 0.07 μM), while compounds 1-3 showed significant cytotoxicity to SMMC-7721 (hepatoma cell line).

Funder

the Project of the Yunnan Forest Resources Cultivation and Utilization Collaborative Innovation Center

Anhui Province Excellent Young Talents Support Program

Wannan Medical College Doctoral Research Startup Fund

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20921621

Reference7 articles.

1. Evaluation of cytotoxic activities of some medicinal polypore fungi from China

2. Antifungal properties of some plant extracts used as wood preservatives

3. Constituents of Fruit Bodies ofTramete orientalis

4. Malonate half-esters of homolanostanoid from an asian Ganoderma fungus

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