Identification of 1,3,4-Thiadiazolyl-Containing Thiazolidine-2,4-dione Derivatives as Novel PTP1B Inhibitors with Antidiabetic Activity

Author:

Li Mengyue1,Li Huiyun23,Min Xiaofeng1,Sun Jinping1,Liang Bingwen1,Xu Lei4,Li Jia435,Wang Shao-Hua6ORCID,Xu Xuetao1ORCID

Affiliation:

1. School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529020, China

2. National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. School of Pharmacy, Zunyi Medical University, Zunyi 563000, Guizhou, China

4. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, Guangdong, China

5. State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

6. School of Pharmacy & State Key Laboratory of Applied Organic Chemistry & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China

Funder

Science and Technology Planning Project of Guangdong Province

National Key Research and Development Program of China

Department of Education of Guangdong Province

Science and Technology Program of Gansu Province

Joint Research Fund for Wuyi University and Hong Kong and Macao

Lanzhou science and technology planning project

Key Project of Jiangmen Basic and Applied Basic Research

Publisher

American Chemical Society (ACS)

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