Free Radical Scavenging Activity-Guided Isolation of a Diterpenoid from Plectranthus punuctatus-Reference-Cited by-同舟云学术

Free Radical Scavenging Activity-Guided Isolation of a Diterpenoid from Plectranthus punuctatus

Published:2011-09 Issue:9 Volume:6 Page:1934578X1100600
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Kebede Wossen¹,Bisrat Daniel²,Asres Kaleab²

Affiliation:

1. Aromatic, Medicinal and Bioenergy Research Case Team Laboratory, Institute of Ethiopian Agricultural Research, Addis Ababa, Ethiopia

2. Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

Abstract

Free radical scavenging activity-guided investigation of the acetone extract of Plectranthus punuctatus (L'Her) (Lamiaceae) resulted in the isolation of a novel diterpenoid 3,11,12,14,19-pentahydroxy-5,8,11,13-abietatraen-7-pyran[4,6]-16-dione whose structure was elucidated based on spectral evidence. The isolated compound showed a significant antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and deoxyribose degradation assays with IC50 values of 9.65 μg/mL and 5.25 μg/mL, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1100600904

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