Saracoside: A New Lignan Glycoside from Saraca indica, a Potential Inhibitor of DNA Topoisomerase IB-Reference-Cited by-同舟云学术

Saracoside: A New Lignan Glycoside from Saraca indica, a Potential Inhibitor of DNA Topoisomerase IB

Published:2012-06 Issue:6 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Mukherjee Tulika¹,Chowdhury Sayan²,Kumar Ashish¹,Majumder Hemanta K²,Jaisankar Parasuraman¹,Mukhopadhyay Sibabrata¹

Affiliation:

1. Chemistry Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata -700032, India

2. Molecular Parasitology Laboratory, Indian Institute of Chemical Biology, Jadavpur, Kolkata -700032, India

Abstract

Chemical investigation of the stem bark of Saraca indica has resulted in the isolation of a new lignan glycoside, saracoside, along with four known lignan glycosides lyoniside, icariside E3, (+)5′methoxyisolarciresinol-9′- O-β-D-glucopyranoside and nudiposide, and a phenolic glucopyranoside, 3,4,5– trimethoxyphenyl-β-D-glucopyranoside, which has been isolated for the first time from this species. The isolated lignan glycosides exhibit potent DNA topoisomerase IB inhibitory activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700619

Reference13 articles.

1. Cytotoxic cyclolignans related to podophyllotoxin

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