A New Ellagic Acid Glycoside and DNA Topoisomerase IB Inhibitory Activity of Saponins from Putranjiva roxburghii-Reference-Cited by-同舟云学术

A New Ellagic Acid Glycoside and DNA Topoisomerase IB Inhibitory Activity of Saponins from Putranjiva roxburghii

Published:2014-05 Issue:5 Volume:9 Page:1934578X1400900
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Kumar Ashish¹,Chowdhury Somenath Roy²,Chakrabarti Tulika³,Majumdar Hemanta K²,Jha Tarun⁴,Mukhopadhyay Sibabrata¹

Affiliation:

1. Chemistry Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata- 700032, India

2. Molecular Parasitology Laboratory, Infectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata -700032, India

3. Chemistry Division, Sir Padampat Singhania University, Udaipur-313601, Rajasthan, India

4. Department of Pharmaceutical Technology, Jadavpur University, Kolkata- 700032, India

Abstract

Chemical investigation of the stem bark and leaves of Putranjiva roxburghii has resulted in the isolation of a new ellagic acid glycoside (5) along with four saponins (1-4). The structures of the isolated compounds were established by detailed spectral analysis. Incidentally putranoside-A methyl ester (4) has been isolated for the first time from this species and the saponins (1-4) exhibited potent DNA topoisomerase IB inhibitory activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900523

Reference10 articles.

1. Wealth of India (2003) Vol 8, CSIR, New Delhi, 325–326.

2. Putraflavone, a new biflavonoid from Putranjiva roxburghii

3. Biflavones from Putranjiva roxburghii

4. Terpenoids and related compounds—XI

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