Spatial Structure and Antimicrobial Activity of Cyclopropane Derivative of Limonene-Reference-Cited by-同舟云学术

Spatial Structure and Antimicrobial Activity of Cyclopropane Derivative of Limonene

Published:2018-04 Issue:4 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Sadyrbekov Daniyar¹,Saliev Timur¹,Gatilov Yuri²,Kulakov Ivan³,Seidakhmetova Roza⁴,Seilkhanov Tulegen⁵,Askarova Sholpan¹

Affiliation:

1. National Laboratory Astana, Nazarbayev University, Unit 9, 53 Kabanbay batyr Ave., Astana, 010000, Kazakhstan

2. N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 9 Ac. Lavrentieva Ave., Novosibirsk, 630090, Russian Federation

3. Omsk F. M. Dostoevsky State University, 55a Mira Ave., 1, Omsk, 644077, Russian Federation

4. Scientific-Production Holding Phytochemistry, Str. M. Gazalieva 4, Karaganda, 100009, Kazakhstan

5. Laboratory of Engineering Profile NMR Spectroscopy, Sh. Ualikhanov Kokshetau State University, Abay Str., 76, 020000, Kokshetau, Kazakhstan

Abstract

A cyclopropane derivative of limonene, (1 S, 4 S, 6 R)-7,7-dichloro-4-[(1 S)-2,2-dichloro-1-methylcyclopropyl]-1-methylbicyclo [4.1.0] heptane (compound 2), was synthesized and its structure was determined by NMR and X-ray crystallographic methods. In addition, an antimicrobial activity of the compound against Gram-positive ( Staphylococcus aureus, Bacillus subtilis) and Gram-negative ( Escherichia coli, Pseudomonas aeruginosa) bacterial strains was also scrutinized.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300401

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