Cancer Chemopreventive Activity of Xanthones from Calophyllum elatum-Reference-Cited by-同舟云学术

Cancer Chemopreventive Activity of Xanthones from Calophyllum elatum

Published:2018-04 Issue:4 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Ito Chihiro¹,Matsui Takuya¹²,Kobayashi Takashi¹,Tokuda Harukuni³,Shanmugam Sivabalan⁴,Itoigawa Masataka⁵

Affiliation:

1. Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan

2. Department of Physiology, School of Medicine, Aichi Medical University, Nagakute, Aichi 480-1195, Japan

3. Organic Chemistry in Life Science, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan

4. Faculty of Science, Annamalai University, Annamalai Nagar 608002, India

5. School of Sport and Health Science, Tokai Gakuen University, 21-233 Nishinohora, Ukigai, Miyoshi, Aichi 470-0207, Japan

Abstract

In our continuing search for compounds with antitumor-promoting activity, we screened eight xanthones isolated from Calophyllum elatum Bedd. (Guttiferae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Several compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Isogarciniaxanthone E (2) showed more potent activity than any of the other compounds tested. Furthermore, isogarciniaxanthone E (2) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300417

Reference18 articles.

1. Chemical Constituents of the Plants of the GenusCalophyllum

2. Chemical and Pharmacological Aspects of the GenusCalophyllum

3. Chemical Constituents of Calophyllum brasiliense. 2. Structure of Three New Coumarins and Cancer Chemopreventive Activity of 4-Substituted Coumarins

4. Chemical Constituents of Calophyllum brasiliensis: Structure Elucidation of Seven New Xanthones and Their Cancer Chemopreventive Activity

5. Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Natural Products as Cancer Chemo Preventive Agents: Where We Stand;Natural Product Communications;2022-12

2. Three isoflavones from Derris scandens (Roxb.) Benth and their cancer chemopreventive activity and in vitro antiproliferative effects;Phytochemistry;2020-07