1. Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan, Tokai Gakuen University, Miyoshi, Aichi 470-0207, Japan, Núcleo de Investigacōes Químico-Farmacêuticas (NIQFAR), Curso de Farmacia/CCS, Universidade do Vale do Itajai (UNIVALI), 88302-202 Itajai, SC, Brazil, and Department of Biochemistry, Kyoto Prefectural University of Medicine, Kamigyou-ku, Kyoto 602-0841, Japan